Lessons from Comparison of Hypoxia Signaling in Plants and Mammals

Hypoxia is an important stress for organisms, including plants and mammals. In plants, hypoxia can be the consequence of flooding causes crop losses worldwide. mammals, may result pathological conditions. Understanding regulation responses to offers insights into novel approaches improvement, particularly development flooding-tolerant crops producing better therapeutics hypoxia-related diseases such as inflammation cancer. Despite their evolutionary distance, mammals deploy strikingly similar mechanisms sense respond different aspects stress, low oxygen levels resulting energy crisis, nutrient depletion, oxidative stress. Over last two decades, ubiquitin/proteasome system ubiquitin-like protein SUMO have been identified key regulators that act in concert regulate core Here, we review ubiquitin SUMO-dependent underlying response By comparing contrasting these this seeks pinpoint conceptually but also highlight future avenues research at junction between fields research.